Fit3D Debunks Dubois Drug Dosing Method

Dubois, Boyd, Gehan & George, Haycock, Mosteller, Costeff, Takahira, Schlich. These are just a few of the named formulas used to measure body surface area (BSA) when weight and height is known. Perhaps the best-known method was created by DuBois and DuBois and first published by The Archives of Internal Medicine in 1916.

DuBois wrapped people in a tight skin of aluminum foil and then measured the body area when the foil is laid flat on the ground. These measurements were the foundation of his mathematical formula; for you lovers of math out there, here it is: BSA = (W 0.425 x H 0.725) x 0.007184. Despite its age, the FDA still uses Dubois’ formula for determining proper drug dosages, but this method is flawed and puts lives at risk.

In an article from the British Journal of Cancer, Dr. Howard Gurney writes, “Body surface area-dosing does not account for the complex processes of cytotoxic drug elimination. This leads to an unpredictable variation in effect. Overdosing is easily recognised but it is possible that unrecognised under-dosing is more common and may occur in 30% or more of patients receiving standard regimen. Those patients who are inadvertently under-dosed are at risk of a significantly reduced anticancer effect. Using published data, it can be calculated that there is an almost 20% relative reduction in survival for women receiving adjuvant chemotherapy for breast cancer as a result of unrecognised under-dosing.”


As the healthcare industry evolves to more personalized medicine, generic standards like Dubois are being set aside for more accurate technology-enabled solutions. 3D body scanners offer a faster and more scientific method for determining individual drug dosages. With a wealth of body data from hundreds of thousands of users, Fit3D can provide millions of measurements – including circumference, joints, contours, landmarks, volume, and body surface – to improve the speed and accuracy of developing proper dosing.

“While there are still many legal and regulatory hurdles to jump, personalized medicine and in particular, individualized drug dosing is having a profound impact on health outcomes,” said Greg Moore, Co-Founder & CEO of Fit3D. “With decreasing patient face-time and tightening financial margins however, healthcare professionals need a time and cost-efficient method for individual risk assessments. The Fit3D ProScanner offers a solution.”

The Fit3D ProScanner takes thousands of measurements of joints, landmarks, circumferences, volumes, surface areas, contours, etc. in 35 seconds. In less than 4 minutes, healthcare professionals can have a complete picture of body composition, posture, and body shape necessary for more accurate dosing.

If your organization is looking for ways to improve health outcomes with personalized solutions, contact a Fit3D Account Executive today at 650-275-3483 or for a demo.